As far as I know, there are companies with a habit of sending a company wide announcement from the Company's president address. Of course the actual person sending those email would be either his/her secretary or other trusted personnel with a delegated access to the president's mail file. So those email would arrive at the user with the president's name on the from field and the real sender of the send by field.
However if said user have out of office enabled, the one that got the reply would be the president instead of the real sender. In my opinion it would make more sense if the one listed on the send by field receive those out of office notification instead since they are the one that send the email.
Being able to toggle this behavior via some sort of server setting would be perfect.