For reasons I find completely unfathomable, the shortcuts to do identical operations are different between the Notes client and the Domino Designer. For instance:
In the client, as it has since the beginning of time, Ctrl-M creates a new mail message. That USED to be the same in the designer but now (I'm on 8.5.1), Ctrl-M in the designer toggles you back and forth between the full screen of whatever panel you're on.
There are a lot of people out here who use keyboard shortcuts ALL THE TIME. It was bad enough when, a few years ago, somebody arbitrarily decided to change the keystrokes that had worked in all the prior versions. To now require us to learn different sets of different keystrokes as we move not only between versions of Notes (we have customers on versions from 5.5 to 8.x) but also between the client and designer...it's ridiculous.